Figure 4.

Deterioration of the skeletal muscle area and increasing muscular fat deposition are a negative prognostic marker for ICI therapy (A) Patient who reveal an increasing L3SMI value at 3 months (positive ∆L3SMI) have a significantly better OS compared to patients with a negative ∆L3SMI. (B) Patient who reveal an increasing MMA value at 3 months (positive ∆MMA) show a strong trend towards a better OS compared to patients with a negative ∆MMA. (C) A strongly decreasing ∆L3SMI (<−6.18 mm²/cm) is associated with a highly significantly reduced OS. (D) A strongly decreasing ∆MMA (<−0.4 mm²/cm) is associated with a significantly reduced OS.