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Regulation of endothelial cell (EC) migration by Rho GTPases. At the leading front, Cdc42 promotes linear actin elongation via mDia2, leading to filopodia formation. Rac1 assembles branched actin networks via WAVE2 complex and Arp2/3, leading to lamellipodia formation. RhoA promotes actomyosin contraction via ROCKs, whereby stress fibers control assembly and disassembly of focal adhesions at the front and the rear, respectively, of migrating ECs.
