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Different binding sites of antagonists on αIIbβ3 integrins. KQAGDV; the primary binding site for fibrinogen and a secondary binding site for abciximab. The binding pocket between subunits; binding site for eptifibatide and tirofiban, therefore competing with fibrinogen. Binding pocket β3; primary binding site for abciximab and echistatin, therefore not competing with fibrinogen.
