Table 2.
List of evaluated aminopeptidase genes (n = 39), sorted by median log2(RPKM) expression from RNAseq data from 122 multiple myeloma patient samples in the FIMM dataset.
| Gene Symbol a | Genomic Location | Median log2(RPKM) Expression (n = 122) | Gene Name a | Peptidase/Protein Family |
|---|---|---|---|---|
| LAP3 | 4p15.32 | 5.00 | Leucine aminopeptidase 3 | M |
| ERAP2 | 5q15 | 4.40 | Endoplasmic reticulum aminopeptidase 2 | M |
| METAP2 | 12q22 | 4.22 | Methionyl aminopeptidase 2 | M |
| TPP2 | 13q33.1 | 4.13 | Tripeptidyl peptidase 2 | S |
| DPP7 | 9q34.3 | 4.04 | Dipeptidyl peptidase 7 | S |
| ERAP1 | 5q15 | 4.03 | Endoplasmic reticulum aminopeptidase 1 | M |
| LTA4H | 12q23.1 | 3.44 | Leukotriene A4 hydrolase | M |
| LNPEP | 5q15 | 2.93 | Leucyl and cystinyl aminopeptidase | M |
| XPNPEP1 | 10q25.1 | 2.66 | X-prolyl aminopeptidase 1 | M |
| METAP1 | 4q23 | 2.46 | Methionyl aminopeptidase 1 | M |
| DPP3 | 11q13.2 | 2.28 | Dipeptidyl peptidase 3 | M |
| DPP8 | 15q22.31 | 2.21 | Dipeptidyl peptidase 8 | S |
| NPEPPS | 17q21.32 | 2.12 | Aminopeptidase puromycin sensitive | M |
| BLMH | 17q11.2 | 1.83 | Bleomycin hydrolase | C |
| JMJD7 | 15q15.1 | 1.78 | Jumonji domain containing 7 | * |
| RNPEP | 1q32.1 | 1.76 | Arginyl aminopeptidase | M |
| PGPEP1 | 19p13.11 | 1.72 | Pyroglutamyl-peptidase I | C |
| TPP1 | 11p15.4 | 1.59 | Tripeptidyl peptidase 1 | S |
| PEPD | 19q13.11 | 1.41 | Peptidase D | M |
| DNPEP | 2q35 | 1.16 | Aspartyl aminopeptidase | M |
| DPP9 | 19p13.3 | 1.16 | Dipeptidyl peptidase 9 | S |
| METAP1D | 2q31.1 | 0.38 | Methionyl aminopeptidase type 1D, mitochondrial | M |
| NPEPL1 | 20q13.32 | 0.37 | Aminopeptidase like 1 | M |
| CTSH | 15q25.1 | 0.36 | Cathepsin H | C |
| XPNPEP3 | 22q13.2 | −0.04 | X-prolyl aminopeptidase 3 | M |
| RNPEPL1 | 2q37.3 | −0.1 | Arginyl aminopeptidase like 1 | M |
| AOPEP | 9q22.32 | −0.38 | Aminopeptidase O (putative) | M |
| KDM8 | 16p12.1 | −1.3 | Lysine demethylase 8 | * |
| ANPEP | 15q26.1 | −2.13 | Alanyl aminopeptidase, membrane | M |
| ENPEP | 4q25 | −2.15 | Glutamyl Aminopeptidase | M |
| MMP14 | 14q11.2 | −2.83 | Matrix Metallopeptidase 14 | M |
| DPP4 | 2q24.2 | −2.84 | Dipeptidyl Peptidase 4 | S |
| NAALADL1 | 11q13.1 | −3.39 | N-Acetylated Alpha-Linked Acidic Dipeptidase Like 1 | M |
| AMZ1 | 7p22.3 | −3.6 | Archaelysin Family Metallopeptidase 1 | M |
| LVRN | 5q23.1 | −3.64 | Laeverin | M |
| CTSV | 9q22.33 | −4.39 | Cathepsin V | C |
| XPNPEP2 | Xq26.1 | −6.15 | X-Prolyl Aminopeptidase 2 | M |
| F11 | 4q35.2 | −6.22 | Coagulation Factor XI | S |
| TRHDE | 12q21.1 | −6.57 | Thyrotropin Releasing Hormone Degrading Enzyme | M |
a Source of gene symbols and names: the HUGO Gene Nomenclature Committee (HGNC); RPKM: reads per kilobase of transcript per million mapped reads; C: cysteine peptidase; M: metallopeptidase; S: serine peptidase; *: Jumonji oxygenase family.