Figure 2.

Schematic illustrating potential role of exosomes in prostate cancer progression. The release of tumor-derived exosomes enhances crosstalk across cells, leading to the progression of a localized PCa into either a metastatic Castration-Sensitive PCa (Mets CSPC) or a non-metastatic Castration-Resistant PCa (Non-mets CRPC). This ultimately leads to the advanced form of the disease; metastatic Castration-Resistant PCa (mCRPC) which can metastasize into various organs of the body such as bone, liver, lungs and lymph nodes.