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. 2021 Mar 30;22(7):3609. doi: 10.3390/ijms22073609

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Selective expression of NLRP3 inflammasome in type II muscle fiber. Serial sections of skeletal muscle show a selective expression of NLRP3 inflammasome in type II muscle fibers. Moreover, aged animals (Group A) show severe muscular atrophy restricted to type II fibers stained white (ATPase pH 4.3) or dark brown (ATPase pH 9.4). In adult animals (Group B) the selective atrophy is mild, and it is absent in muscle of young animals (Group C). Immunohistochemistry was performed with HRP method and Mayer’s hematoxylin counterstain.