Table 1.
Genomic DNA fragmentation coefficient in circulating blood nucleated cells and some morphometric indices of the heart, kidney and liver status in rats exposed to lead oxide (PbO–NP) and/or cadmium oxide (CdO–NP) nanoparticles ( ± s.e.).
| Index | Groups of Rats Exposed to: | |||
|---|---|---|---|---|
| Water (Control) | CdO–NP | PbO–NP | CdO–NP + PbO–NP | |
| Blood nucleated cells | ||||
| Coefficient of genomic DNA fragmentation | 0.4123 ± 0.0028 | 0.4452 ± 0.0004 * | 0.4358 ± 0.0003 *● | 0.5817 ± 0.0016 *●# |
| Heart | ||||
| Right ventricular cardiomyocyte thickness, µm | 3.06 ± 0.09 | 3.07± 0.09 | 2.80 ± 0.07 * | 2.65 ± 0.08 *● |
| Kidneys | ||||
| Glomeruli diameter, µm | 40.08 ± 1.09 | 42.65 ± 1.75 | 32.90 ± 1.01 *● | 42.43 ± 0.98 # |
| Epithelial desquamation, % | 0.0 ± 0.0 | 63.06 ± 12.09 * | 21.73 ± 5.51 *● | 44.28 ± 8.83 *# |
| Brush border loss, % | 6.70 ± 1.90 | 45.18 ± 5.03 * | 33.54 ± 5.44 * | 57.12 ± 5.69 *# |
| Liver | ||||
| Akaryotic hepatocytes, % | 11.38 ± 0.65 | 22.30 ± 1.79 * | 14.95 ± 0.90 *● | 29.35 ± 2.24 *●# |
| Binuclear hepatocytes, % | 3.82 ± 0.43 | 3.20 ± 0.67 | 5.35 ± 0.53 *● | 2.85 ± 0.42 # |
| Kupffer cells, % | 10.55 ± 0.36 | 24.40 ± 1.00 * | 23.75 ± 1.29 * | 20.45 ± 1.20 *● |
Notes: The superscripts designate values which are statistically significantly different from the corresponding values for the control group (*), for the “CdO–NP” (●) or for the “PbO–NP” (#) (p < 0.05 by Student’s t–test).