Table 4.
Myocardium Characteristics | Group of Rats | ||
---|---|---|---|
Controls | Exposed to CdO–NP + PbO–NP |
Exposed to CdO–NP + PbO–NP along with BPC |
|
Expression of α–MHC, % | 92 ± 3 | 61 ± 3 * | 85 ± 2 *▪ |
Expression of β–MHC, % | 8 ± 3 | 39 ± 3 * | 15 ± 3 *▪ |
Sliding velocity of thin filaments over myosin (VMAX), µm/s | 4.90 ± 0.15 | 4.63 ± 0.22 * | 4.81 ± 0.27 ▪ |
Velocity of trabeculae at working length corresponding to 0.95 LMAX and load corresponding to 0.9 P/P0, VMAX/Lw | 0.53 ± 0.03 | 0.35 ± 0.03 * | 0.54 ± 0.03 ▪ |
End–systolic length of trabeculae at working length corresponding to 0.95 LMAX and load corresponding to 0.6 P/P0, L/Lwork | 0.94 ± 0.01 | 0.96 ± 0.00* | 0.95 ± 0.01 ▪ |
Note: *—statistically significant difference from the control group, ▪—statistically significant difference from the group exposed to NPs (p < 0.05, Mann–Whitney U-test).