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. 2021 Mar 31;22(7):3645. doi: 10.3390/ijms22073645

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Morphological evaluation of telocytes in formalin-fixed and paraffin-embedded tissue sections from control EDL muscles, EDL muscles damaged by ex vivo forced eccentric contraction (EC) and EDL muscles damaged by EC in the presence of bone marrow-mesenchymal stromal cell (MSC) conditioned medium (EC + MSC-CM). (a–d) Representative confocal immunofluorescence images of muscle tissue sections immunostained with antibodies against CD34 (red) and the pan-endothelial cell marker CD31 (green). Telocytes are identified as CD34⁺/CD31⁻ stromal cells with distinctive moniliform cytoplasmic prolongations (telopodes), while vascular structures are CD31⁺. Higher magnification of the boxed area in (b) depicting a typical telocyte is shown in the inset. Images are representative of at least 3 sections from each of 4 control, 4 EC and 4 EC + MSC-CM muscles. Scale bars = 25 μm (a–d), 10 μm (inset in b).