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. 2021 Mar 25;22(7):3392. doi: 10.3390/ijms22073392

Figure 2.

Figure 2

Transcriptional response to SARS-CoV-2 infection of Calu-3 cells is dominated by antiviral defense genes. (A) Volcano plot showing global transcriptional changes of ~11,000 genes in SARS-CoV-2 infected Calu-3 cells. Log2FoldChange infected 24 h versus mock. 229 transcripts were differentially expressed (DE) in SARS-CoV-2 infected cells based on the cut-off of p-value < 0.05, log2fold change > 1. (B) Significantly altered genes were submitted to https://david.ncifcrf.gov/ (accessed on 23 March 2021) for Functional Annotation Clustering. Here, Uniprot Keywords were summarised using fold enrichment of DE genes, coloured by PValue. (C) Common genes between Uniprot “Antiviral Defense” keywords and the 229 SARS-CoV-2 DE genes.