Table 1.
The inhibitory effect of polyphenol compounds on SARS-CoV-2 Mpro.
| No | Compound | Group | Source | Inhibition (%) | IC50 (μM) |
|---|---|---|---|---|---|
| 1 | Black garlic extract | Mixtures | SerimFood | 100 | 137 ± 10 μg/mL |
| 2 | Tannic acid | Tannoid | Sigma | 100 | 9 |
| 3 | Puerarin | Isoflavone | Sigma | 100 | 42 ± 2 |
| 4 | Daidzein | Isoflavone | Sigma | 100 | 56 |
| 5 | Genistin | Isoflavone | Sigma | 48 | ND |
| 6 | Myricetin | Flavonol | Sigma | 80 | 43 ± 1 |
| 7 | Quercetin | Flavonol | Sigma | 74 | 93 ± 5 |
| 8 | Astragalin | Flavonol | Amore Pacific | 61 | 143 ± 9 |
| 9 | Quercetagenin | Flavonol | Sigma | 58 | 145 ± 6 |
| 10 | Rutin | Flavonol | Sigma | 45 | ND |
| 11 | Quercetin-4′-O-α-d-glucopyranoside | Flavonol | Synthesized | 26 | ND |
| 12 | Kaempferol | Flavonol | Sigma | 16 | ND |
| 13 | Ampelopsin | Flavanonol | Sigma | 64 | 128 ± 5 |
| 14 | Ampelopsin-4′-O-α-d-glucopyranoside | Flavanonol | Synthesized | 50 | 195 ± 5 |
| 15 | Naringenin | Flavanone | Sigma | 57 | 150 ± 10 |
| 16 | Hesperidin | Flavanone | Sigma | 22 | ND |
| 17 | Naringin | Flavanone | Sigma | 18 | ND |
| 18 | Epigallocatechin gallate (EGCG) | Flavan-3-ols | Sigma | 53 | 171 ± 5 |
| 19 | Gallocatechin gallate | Flavan-3-ols | Sigma | 50 | ND |
| 20 | Epigallocatechin (EGC) | Flavan-3-ols | Sigma | 23 | ND |
| 21 | Catechin gallate (CG) | Flavan-3-ols | Sigma | 21 | ND |
| 22 | Epicatechin gallate (ECG) | Flavan-3-ols | Sigma | 21 | ND |
| 23 | Catechin | Flavan-3-ols | Sigma | 9 | ND |
| 24 | Epicatechin (EC) | Flavan-3-ols | Sigma | 8 | ND |
| 25 | Vitexin | Flavone | Sigma | 52 | 180 ± 6 |
| 26 | Luteolin | Flavone | Sigma | 45 | ND |
| 27 | Apigenin | Flavone | Sigma | 25 | ND |
| 28 | Chrysin | Flavone | Sigma | 9 | ND |
| 29 | Resveratrol | Stilbenoid | Sigma | 68 | 103 ± 6 |
| 30 | Chlorogenic acid | Hydrocinnamic acid | Sigma | 61 | 140 |
| 31 | Caffeic acid | Dihydroxycinnamic acid | Sigma | 50 | 197 ± 1 |
| 32 | Demethoxycurcumin (DMC) | Diarylheptanoid | TCI chemical | 48 | ND |
| 33 | Bisdemethoxycurcumin (BDMC) | Diarylheptanoid | TCI chemical | 34 | ND |
| 34 | Curcumin | Diarylheptanoid | TCI chemical | 41 | ND |
| 35 | Ferulic acid | Hydrocinnamic acid | Sigma | 46 | ND |
| 36 | Mangiferin-(1- > 6)-α-d-glucopyranoside | Xanthonoid | Synthesized | 40 | ND |
| 37 | Mangiferin | Xanthonoid | Sigma | 35 | ND |
| 38 | Icaritin | Favonol | Sigma | 31 | ND |
| 39 | Salicin | Salicylate | Sigma | 20 | ND |
| 40 | Pyrogallol | Benzenetriol | Sigma | 14 | ND |
| 41 | Gallic acid | Sigma | 7 | ND | |
| 42 | Ascorbic acid | Sigma | 4 | ND | |
| 43 | Catechol | Bezenediol | Sigma | 3 | ND |
| 44 | Hydroquinone | Sigma | 3 | ND | |
| 45 | Trigonelline | Alkaloid | Sigma | 1 | ND |
| 46 | Caffein | Alkaloid | Sigma | 0 | ND |
| 47 | Idebenone | 1,4-benzoquinone | TCI chemical | 0 | ND |
| 48 | Salicylic acid | Monohydroxybenzoic acid | Sigma | 0 | ND |
| 49 | Capsaicin | Capsaicinoid | Sigma | 0 | ND |
| 50 | Teniposide | Podophyllotoxin | Sigma | 0 | ND |