Table 1.

Echocardiographic analysis of control and Nmrk2 KO mice at baseline and after 2 weeks of TAC.

Cardiac Parameters	Baseline		TAC Day 15		ANOVA
	Wt	Nmrk2-KO	Wt	Nmrk2-KO
N	3	5	3	5
IVSThD (cm)	0.06 ± 0.006	0.06 ± 0.005	0.1 ± 0 ***	0.09 ± 0.008 ***, #	i, ¶¶¶
LVEDD (cm)	0.34 ± 0.006	0.34 ± 0.028	0.35 ± 0.015	0.39 ± 0.043
LVPWThD (cm)	0.07 ± 0.006	0.08 ± 0.008	0.09 ± 0.007	0.08 ± 0.007	¶
IVSThS (cm)	0.11 ± 0.006	0.11 ± 0.007	0.14 ± 0 *	0.12 ± 0.013 #	¶, §
LVESD (cm)	0.18 ± 0.006	0.19 ± 0.024	0.2 ± 0.017	0.27 ± 0.065
LVPWThS (cm)	0.11 ± 0.010	0.12 ± 0.008	0.14 ± 0.006	0.11 ± 0.010 ##	i, §
EDV (mL)	0.1 ± 0	0.11 ± 0.023	0.11 ± 0.0	0.16 ± 0.051
ESV (mL)	0.02 ± 0	0.02 ± 0.007	0.02 ± 0.007	0.06 ± 0.041
LVEF (%)	81.7 ± 0.87	81.8 ± 2.47	80.6 ± 2.79	65.8 ± 13.98 *
FS (%)	44.5 ± 1.12	44.54 ± 2.58	43.3 ± 2.73	32.1 ± 9.54 *, #
SV (mL)	0.08 ± 0	0.09 ± 0.018	0.09 ± 0.006	0.1 ± 0.019
h/r	0.41 ± 0.021	0.42 ± 0.048	0.55 ± 0.020 *	0.44 ± 0.049 ##	¶, §
HR (bpm)	610 ± 12.4	613 ± 15.1	566 ± 12.9	541 ± 55.6	¶
LVMI (mg/g)	2.92 ± 0.320	3.49 ± 0.441	5.01 ± 0.747 §§	5.56 ± 1.059 ###	¶¶

Mice series related to Figure 3. Abbreviations: IVSThD and IVSThD, interventricular septum thickness, in diastole and systole, respectively LVEDD and LVESD, left ventricle (LV) end-diastolic and end-systolic diameter; LVPWTh, LV posterior wall thickness; EDV and ESV, end-diastolic and end-systolic volume; LVEF, LV ejection fraction; FS, fractional shortening; h/r, LV mean wall thickness/radius ratio; HR, heart rate in beats per minute. Two-way repeated measure ANOVA for independent samples: i, p ≤ 0.05 for the interaction effect; ¶, p ≤ 0.05; ¶¶, p ≤ 0.01; ¶¶¶ p ≤ 0.001 for the TAC effect; § p ≤ 0.05, ^§§ p ≤ 0.01 for the genotype effect. Post-hoc Sidak’s multiple comparison test: *, p ≤ 0.05; ***, p ≤ 0.001 TAC vs baseline within the same genotype; #, p ≤ 0.05, ##; p ≤ 0.01; ###, p ≤ 0.001, Nmrk2-KO mice vs Wt within the TAC group.