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Over and aberrant expression of RARγ in human cancers.
| Malignancy | RARγ Expression | Impact on Disease |
|---|---|---|
| Acute myeloid leukemia | RARγ chimeric protein | Not responsive to retinoid-based therapy |
| Colorectal carcinoma | Overexpression | Resistance to chemotherapeutics |
| Cholangiocarcinoma | Overexpression | Poor prognosis and drug resistance |
| Hepatocellular carcinoma | Overexpression | Promotes growth of xenografts |
| Renal cell carcinoma | Overexpression | May contribute to disease progression |
