Table 5.
Transcription factors affected by tert-butylhydroquinone and other compounds in ToxCast assays.
| Gene Name and Function | ToxCast Assay Name | TBHQ | FD&C Red 3 | 6:2 FTOH | PFOS | PFOA | PFUnDA |
|---|---|---|---|---|---|---|---|
| Aryl hydrocarbon receptor (AhR) Involved in xenobiotic response |
ATG_Ahr_CIS_up | ✓ | |||||
| OX21_AhR_LUC_Agonist * | ✓ | ||||||
| Nuclear factor, erythroid 2-like 2 (NFE2L2, Nrf2) Involved in oxidative stress, inflammation, and injury |
ATG_NRF2_ARE_CIS_up | ✓ | ✓ | ✓ | ✓ | ||
| TOX21_ARE_BLA_agonist_ratio | ✓ | ✓ | |||||
| Glucocorticoid receptor (nuclear receptor subfamily 3, group C, member 1) Involved in regulation of stress response, inflammation, and immune processes |
NVS_NR_hGR | ✓ | ✓ | ||||
| TOX21_GR_BLA_Antagonist_ratio | ✓ |
Note: * This assay had an AC50 value greater than the calculated cytotoxicity limit for TBHQ.