Figure 2.

NK cell, blast cell and soluble factors in NK cell-AML immunoediting. ROS = reactive oxygen species; NCR = natural cytotoxicity receptor; LFA-1 = lymphocyte function-associated antigen 1; RANK = receptor activator of nuclear factor kappa-Β; TIGIT = T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif (ITIM) domain; DNAM-1 = DNAX accessory molecule-1; PD-1 = programmed cell death protein 1; iKIR = inhibitory killer immunoglobulin receptor; MDSC = myeloid derived suppressor cell; Treg = regulatory T-cell; mbTGF-β = membrane bound transforming growth factor beta; PD-L1 = programmed death-ligand 1; IDO = indoleamine 2,3-dioxygenase; GSK3β = Glycogen synthase kinase-3β.