Table 1.

Activities of the two different forms of CXCL16.

Ligand	Receptor	Activated Signaling Pathways	Physiological Significance	References
sCXCL16	CXCR6	G protein-coupled receptor, PKB, ERK MAPK, calcium mobilization	Proliferation, migration, fibrosis, VEGF and CXCL8/IL-8 expression	[7,12,24,25,26,27,28,29,30,31,32,33]
sCXCL16	mCXCL16	insensitive to pertussis toxin, ERK MAPK, PKB	Proliferation, apoptosis resistance	[21,23]
CXCR6	mCXCL16	insensitive to pertussis toxin, ERK MAPK	Migration but not proliferation	[22,23]
mCXCL16	CXCR6		Cell adhesion	[12,20]