Figure 7.

Anticancer drugs cause neuronal injury, and flavonoids counter these effects; (a) Simplified Overview of how flavonoids counter neuronal injury induced by anticancer drugs (b) Mechanisms of neuronal injury by anticancer drugs. Mitochondrial damage and sensitization of primary afferent channels cause ectopic discharges, which contribute to spontaneous pain, ongoing pain, and mechanical hypersensitivity; (c) Flavonoids alleviate neuronal damage caused by anticancer drugs, reducing spontaneous pain, mechanical hypersensitivity, and the likelihood of apoptosis.