Table 6.

Studies investigating the effects of flavonoids on CIPN models.

Flavonoid	Neuropathic Pain Model	Animal	Mode of Administration/ Concentration of Flavonoid	Mechanism-based Intervention	Effect on Neuropathy	Reference
Quercetin	Paclitaxel induced	adult male Sprague-Dawley rats and mice	3, 10 and 30 μmol/L (in vitro) Intragsteral administration of 20 mg/kg or 60 mg/kg once per day for 40 days for rats and 12 days for mice (in vivo)	Inhibited degranulation of mast cells and membrane translocation of PKC epsilon	Dose dependent increase of thermal hyperalgesia and mechanical allodynia thresholds	[41]
Icariin	Paclitaxel induced	Male Sprague Dawley rats	IG/25, 50, 100 mg/kg.	Suppressed GFAP and astrocyte production of TNF-α, IL-1b, and IL-6.	Alleviated mechanical allodynia (100 mg/kg in the long term) and spinal neuroinflammation.	[42]