Table 8.

Previous studies investigating the effects of flavonoids on CIPN models.

Flavonoid	Neuropathic Pain Model	Animal	Mode of Administration/Concentration of Flavonoid	Mechanism-based Intervention	Effect on Neuropathy	Reference
Icariin	Paclitaxel induced	Male Sprague Dawley rats	IG/25, 50, 100 mg/kg	Suppressed GFAP and astrocyte production of TNF-α, IL-1β, and IL-6.	Alleviated mechanical allodynia (100 mg/kg in the long term) and spinal neuroinflammation.	[42]
Astragali radix	Oxaliplatin-induced neurotoxicity	Male Sprague Dawley rats	50% hydroalcoholic extracts of Astragali radix	Numerical reduction of astrocytes within the dorsal horns (demonstrated by GFAP immunohistochemistry)	Reduction of Oxaliplatin-induced molecular and morphometric alterations in peripheral nerve and dorsal-root ganglia. Decrease in the activation of microglia and astrocytes	[73]