Table 9.

Previous studies investigating the mechanisms by which anticancer drugs exert their effects.

Mechanism of CIPNP	Neuropathic Pain Model	Mode of Administration/Concentration	Animal	Reference
Downregulation of MnSOD through post translational nitration by peroxynitrite.	Paclitaxel, oxaliplatin, bortezomib	Intraperitoneal; Paclitaxel: 4 doses delivered on alternate days, cumulative dose of 8 mg/kg Oxaliplatin: 10 mg/kg delivered over 5 consecutive days Bortezomib: 1 mg/kg delivered over 5 consecutive days	Male Sprague Dawley rats	[91]
Formation of DNA adducts	Cisplatin	2 microgram/ml for 48 h (in vitro)	Harlan–Sprague–Dawley rats and wild type background mice (C57BL/6J)	[85]
Increased permeability of mPTP	Paclitaxel	Intraperitoneal/ 1 ml/kg on 4 alternate days (in vitro and in vivo)	Adult male Sprague–Dawley rats	[92]
Increased LPS-induced iNOS expression	Oxaliplatin	i.v./nine injections of 1 mg/kg each given twice a week (in vitro and in vivo)	male Swiss mice	[56]