Table 10.

Previous studies investigating the effects of flavonoids on CIPN models.

Flavonoid	Neuropathic Pain Model	Animal	Mode of Administration/Concentration of Flavonoid	Mechanism Based Intervention	Effect on Neuropathy	Reference
Genistein	Chronic constriction sciatic nerve injury	C57BL/6J male mice	Subcutaneously/once a day for 11 days at doses of 1,3,7.5,15,30 mg/kg (in vitro and in vivo)	Restoration of mitochondrial GPX levels, and reduction of LPS-induced iNOS production	Reversal of mechanical allodynia and thermal hyperalgesia in a time and dose-dependent manner	[81]
Morin	Chronic constriction injury	Male Sprague-Dawley rats	Oral/30 mg/kg for 14 days (in vitro and in vivo)	Reduced PARP overactivation and nitrite levels. Restored ATP and glutathione levels; repaired DNA damage	Reversed mechanical, chemical, and thermal hyperalgesia	[78]
Isoorientin	Chronic constriction injury	Adult, male specific pathogen free mice from ICR	Intragastric/7.5, 15 or 30 mg/kg per day	Ameliorated axonal swelling; prevented demyelination	Reduced hyperalgesia and allodynia	[80]
Quercetin and rutin	Oxaliplatin induced	male Swiss mice	i.v./nine injections of rutin (25, 50, and 100 mg/kg) or quercetin (25, 50, and 100 mg/kg) given twice a week (in vitro and in vivo)	Decreased LPS-induced iNOS expression	Inhibition of thermal and mechanical hyperalgesia	[56]
GSPE	Chronic constriction injury	Wistar rats of either sex	Oral/100 and 200 mg/kg for 14 days (in vitro and in vivo)	Increased SOD and GSH	Attenuation of thermal hyperalgesia and mechanical allodynia	[79]
Silibinin	Oxaliplatin	Rat model of painful oxaliplatin-induced neuropathy	Silibinin (100 mg/kg), administered once a day, starting from the first day of oxaliplatin injection until the 20th	Prevention of oxidative damage	Antineuropathic effects	[90]