Table 1.
The 12 genes of VirB operon and their respective function Brucella. abortus, Brucella. melitensis and Brucella. Ovis [25,26,27,28,29].
| Operon | Whether or Not the Virulence Decreases after Deletion | Function | ||
|---|---|---|---|---|
| Brucella. abortus | Brucella. melitensis | Brucella. ovis | ||
| VirB1 | decrease | unknown | unknown | Dissolves glycosyltransferase, which makes T4SS easier to assemble and assemble. |
| VirB2 | decrease | decrease | decrease | Participate in the immune protection of the body and affect the production of immune protection. |
| VirB3, VirB6, VirB7, VirB10 | decrease | unknown | unknown | Signal transmission of bacterial transmembrane proteins. |
| VirB4 | decrease | decrease | unknown | Transport substances and effectively prevent BCV and dissolution Enzyme fusion. |
| VirB5, VirB8 | decrease | unknown | unknown | Regulation of intracellular transport in Brucella. |
| VirB9 | decrease | decrease | unknown | As a part of the outer membrane of Brucella type IV secretion system, it can stimulate the body to produce immune responsean. |
| VirB11 | decrease | unknown | unknown | It provides energy for the secretion process of Brucella. |
| VirB12 | unchanged | unchanged | unchanged | Immune antigen. |