Table 1.
TNF-α and TRAIL mutants.
| Based on | Protein | Format | Modification | Affinity | Ref. |
|---|---|---|---|---|---|
| TNF-α | Mutant 471 | 1-7del + P8R/S9K/D10R | [81] | ||
| mutant R32w | R32w | TNF-R1 | [82] | ||
| Mutant M3 | 1-7del + S52I, Y56F | TNF-R1 | [83] | ||
| RGD-V29 | includes cell adhesive sequence (R4, G5, D6) + R29V | TNF-R1 | [84] | ||
| rmhTNF | 1-7del + P8R/S9K/D10R/L157F | [85] | |||
| TRAIL | TRAIL.R1-5 | TRAIL (aa 95–281) |
Q193S/N199 V/K201R/Y213 W/S215N | DR4 | [86] |
| 4c7 | TRAIL (aa 114–281) |
G131R/R149I/S159R/ N199R/K201H/S215D |
DR4 | [87] | |
| rTRAIL DR4 | S159R | DR4 | [88] | ||
| FLAG-Apo2L.DR5–8 Trp-213; |
TRAIL (aa 96–281) |
Y189 N/R191 K/Q193R/H264R/ I266L/D267Q |
DR5 | [89] | |
| DHER | TRAIL (aa 114–281) |
D269H and E195R | DR5 | [90] | |
| DR5-A | TRAIL (aa 114–281) |
Y189 N/R191 K/Q193R/H264R/ I266L/D267Q/D269H | DR5 | [91] | |
| DR5-B | TRAIL (aa 114–281) |
Y189 N/R191 K/Q193R/H264R/ I266L/D269H | DR5 | [91] | |
| TRAIL-Mu3 | TRAIL (aa 114–281) |
aa 114–121 (VRERGPQR) were replaced by RRRRRRRR | DR4 and DR5 | [92] |