Table 2.

Non-exhaustive list ¹ of monoclonal antibodies (mAbs) and nanobodies (Nbs) that target TAFI or activated TAFI (TAFIa).

		Mechanism	Epitope Residues	Ref.
mAbs	MA-RT36A3F5	Destabilizes TAFIa	Arg188, His192	[113]
	MA-RT13B2	Destabilizes TAFIa;	Arg227, Ser251	[113]
		Directly inhibits TAFIa
	MA-RT30D8	Directly inhibits TAFIa	Arg227, Ser249, Ser251, Tyr260	[113]
	MA-RT82F12	Directly inhibits TAFIa	Arg227, Ser249, Ser251, Tyr260	[113]
	MA-TCK27A4	Inhibits P-, T-, and T/TM-mediated TAFI activation	Phe113	[48]
	MA-T12D11	Inhibits T/TM-mediated TAFI activation	Gly66	[114]
	MA-T94H3	Inhibits T/TM- and P-mediated TAFI activation	Val41	[114]
	MA-T1C10	Inhibits T/TM- and P-mediated TAFI activation	Gln45	[114]
	MA-TCK22G2	Inhibits P- and T-mediated TAFI activation	Thr147, Ala148	[48]
	MA-TCK11A9	Inhibits P-mediated TAFI activation;	Lys268, Ser272, Arg276	[48,115]
		Directly inhibits TAFIa activity on fibrin
	MA-TCK26D6	Inhibits P-mediated, and to a lesser extent, T-mediated TAFI activation;	Asp87, Thr88	[49,115]
		Directly inhibits TAFIa activity on fibrin
Nbs	VHH-mTAFI-i49	Stimulates TAFI activity	Arg227, Lys212	[116]
		Destabilizes TAFI
	VHH-a204	Inhibits P-, T-, and T/TM-mediated TAFI activation	Arg117, His118, His175,	[35,117]
			Gln178, Ile182, Gln184,
			Tyr186, Arg384
	VHH-i83	Inhibits P- and T/TM-mediated TAFI activation;	Arg12, Gln33, Gln45, Ser70,	[117]
			Val71, Gln292, Arg330,
		Directly inhibits TAFIa	Thr367, Thr369

¹ This list only includes mAbs and Nbs for which the epitope has been mapped my mutagenesis or X-ray crystallographic studies.