Table 2.
SSAO/VAP-1 is involved in the binding/transmigration of different types of leukocytes, but not of other types. This selectivity also depends on the organ studied and the inflammatory stimulus.
| Inflammatory Stimulus | Organ/Tissue | Type of Leukocytes Bound by SSAO/VAP-1 | Type of Leukocytes not Bound by SSAO/VAP-1 | Reference |
|---|---|---|---|---|
| Ischemia/reperfusion | Kidney | Neutrophils | Macrophages/T-lymphocytes | [65] |
| Postischemic inflammation | Brain | Neutrophils | - | [66] |
| Subarachnoid hemorrhage | Brain | Neutrophils | - | [67] |
| Intracerebral hemorrhage | Brain | Neutrophils | - | [68] |
| Peritonitis | Peritoneum | Granulocytes | - | |
| Air pouch inflammation | Subcutaneous | Monocytes/lymphocytes | - | [69] |
| LPS | Brain | Neutrophils | - | [70] |
| LPS, Klebsiella pneumoniae | Lungs | Polymorphonuclear cells, neutrophils | - | [71] |
| Acute liver failure | Liver | Leukocytes | Monocytes | [72] |
| ConA hepatitis | Liver | CD4+ Th2 cells | - | [73] |
| Hepatic chronic inflammation and fibrosis | Liver | CD16+ monocytes | - | [74] |
| Liver inflammation | Liver | CD4+ T cell | - | [75] |
| Liver allograft rejection | Liver | CD4+ and CD8+ lymphocytes | - | [76,77] |
| Tumors (adhesion function) | Skin | CD45+, CD3+, CD8+ | CD4+, T-reg cells, Type2 macrophages, GR-1+CD11b+ | [78] |
| Tumors (enzymatic function) | Skin | CD45+, CD8+, CD11b+, granulocytes, | CD4+, type2 macrophages | [78] |
| Cytokine-induced angiogenesis | Eyes | CD11b+ cells, granulocytes | - | [79] |
| Diabetic retinopathy | Eyes | Leukocytes | - | [80] |
| Uveitis | Eyes | CD45+ | - | [81] |
| In vitro | Endothelial cells | Lymphocytes, T-killer cells | Neutrophils, monocytes | [82] |
| In vitro | Endothelial cells | Polymorphonuclear leukocytes | - | [83] |
| AOC3 knockout | Adipose tissue | CD45+, T cells, macrophages, natural killer | - | [84] |