Table 3.
Perioperative serum concentration of syndecan-1 and heparan sulfate.
| Variable | Tranexamic Acid n = 60 |
Control n = 61 |
p-Value † | ||
|---|---|---|---|---|---|
| Syndecan-1 (ng/mL) | p-Value * | p-Value * | |||
| T0 | 30.0 (19.6–41.2) | 27.3 (19.4–37.1) | |||
| T1 | 28.4 (18.7–38.0) | 0.063 | 28.8 (19.7–36.9) | 0.005 | 0.617 |
| T2 | 32.6 (20.1–43.0) | 0.324 | 30.7 (22.1–40.9) | <0.001 | 0.907 |
| T0-T1 difference | −1.6 (−5.3–2.6) | 2.2 (−0.7–4.8) | 0.001 | ||
| T0-T2 difference | 0.0 (−3.3–5.5) | 3.6 (−0.1–9.3) | 0.013 | ||
| Heparan sulfate (ng/mL) | |||||
| T0 | 1.7 (1.0–2.5) | 1.6 (0.9–2.9) | 0.762 | ||
| T1 | 2.2 (1.3–4.2) | <0.001 | 1.9 (1.1–3.4) | <0.001 | 0.544 |
| T2 | 2.7 (1.8–4.2) | <0.001 | 2.7 (1.5–4.4) | <0.001 | 0.893 |
| T0-T1 difference | 0.4 (0.1–1.0) | 0.2 (0.0–0.9) | 0.272 | ||
| T0-T2 difference | 0.8 (0.3–1.8) | 0.9 (0.4–1.7) | 0.998 | ||
Values are median (interquartile range); * p-value drawn from Wilcoxon signed-rank test to compare the concentrations of the paired serum markers at T1 and T2 from T0; † p-value drawn from Mann–Whitney U tests for comparison between the two groups. T0, preoperative baseline; T1, end of surgery; T2, 2 h post-surgery.