Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Mechanisms of autoimmunity. The pathogenic mechanisms of autoimmunity involve a genetic susceptibility (i.e., HLA genotype, cytokine polymorphisms, etc.) and the occurrence of acquired, environmental factors (i.e., infectious agents, neoplastic clones, medical/cellular therapies). HLA human leukocyte antigens, IGHV immunoglobulin heavy variable, CTLA-4 cytotoxic T-lymphocyte antigen-4, LT-α lymphotoxin-α, CPI checkpoint inhibitors, HSCT hematopoietic stem cell transplant.
