Table 2.
Cannabinoids’ effects on signaling pathway of EMT, adhesion, invasion, metastasis, and angiogenesis.
| MEDIATORS | EFFECTS | REF | |
|---|---|---|---|
| Epithelial Mesenchimal Transition (EMT) | JWH-015 THC CBD WIN AEA |
InhibitionWnt/ßcatenina:Downregulation of Snail, Twist, Slug, Vimentin, Fibronectin; Upregulation of E-Cadherin. Inhibition of p27/CDK4/pRb. |
[120] [119] |
| AM251 | Downregulation of Snail1, Fos-b,Jun-b, Ap1. | [119] | |
| Adhesion | AM251 | TGFß inhibit Smad2/3-p38MAPK: Downregulation of COL1A1 e Upregulation of E-Cadherin | [119] |
| Invasionand metastasis | THC CBD WIN AEA |
Inhibition Id1 and Sox2. Relase of extracellular vesicles with miR-29b1. Inhibition of Cox-2 and of phosphorylation AKT and inhibition of MMP2;FAK,MMP-9,VCAM1 |
[101] [104] [106] |
| Angiogenesis | JWH-015 THC CBD WIN |
Inhibition of Cox-2 and phosphorylation of AKTand inhibition of MMP2; FAK; MMP-9; VCAM. Binding CXCR4 Activation of ICAM-1 and Timp1 |
[90,117] [92] [112] |