Table 2.
Summary of INa patch clamp data. (#: p ≤ 0.05, WT vs. Trpm4−/−).
| Atrial | Ventricular | |||
|---|---|---|---|---|
| WT | Trpm4 −/− | WT | Trpm4 −/− | |
| Cm (pF) | 62.2 ± 3.8 | 50.8 ± 2.4 # | 187.7 ± 16.7 | 164.5 ± 10.9 |
| INa-peak density (pA/pF) | −48.0 ± 2.3 | −36.3 ± 2.6 # | −36.0 ± 4.4 | −25.6 ± 1.6 # |
| V1/2 of activation (mV) | −38.6 ± 1.4 | −34.3 ± 0.9 # | −34.7 ± 0.1 | −32.4 ± 0.1 |
| k of activation | 4.0 ± 0.2 | 5.2 ± 0.2 # | 5.6 ± 0.1 | 5.5 ± 0.1 |
| V1/2 of inactivation (mV) | −75.0 ± 1.9 | −76.2 ± 1.4 | −75.5 ± 0.1 | −74.9 ± 0.9 |
| k of inactivation | 6.2 ± 0.1 | 6.1 ± 0.1 | 6.0 ± 0.1 | 6.6 ± 0.1 |