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Performance of the four-miR classifier tested in the Gene Expression Omnibus (GEO) dataset. (A) Database searching, inclusion and exclusion criteria. (B) Among 16 studies found in the GEO datasets, 7 fulfilled the criteria of number of samples (≥20 samples of both CRC and controls), 5 used serum samples and validated our four-miR classifier model, and 3 datasets (exosome, serum, and plasma samples) showed no significant association.
