Figure 7.

Evaluation of the association between the TME components and clinical response to ICB in different cancer types and therapies. (A) Scatterplot showed correlation of the abundance of TME components with ICB response in specific cancer type with different ICB therapy. Red dots denoted that the abundance of TME component was higher in responders than non-responders, green dots indicated the opposite. Size of dots indicated significance (larger for p < 0.05) and p value was computed by the two-sided Wilcoxon rank-sum test. Colors of different datasets indicated different ICB treatment strategies. (B) Prediction performance of each TME component for ICB response across different cancer and treatment types. AUC for each component across benchmark datasets were shown at left panel. The cancer type-specific and treatment type-specific prediction scores (sum of sample size-weighted AUC) were shown at right panel. The gradient of color indicated the prediction performance from low (light) to high (dark).