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Receptor tyrosine kinase activation in WT and hSDC1+/+ livers 6 months after DEN exposure. Except for pMusk, significant inhibition of all receptors was detected in hSDC1+/+ livers. Heparan sulfate (HS) binding epidermal growth factor (EGF) establishes heterodimer with shed hSDC1 binding together to EGFR and facilitate the activation of the receptor. Data points represent the mean ± SD, n = 3; * p < 0.05; ** p < 0.01.
