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. 2021 Apr 1;22(7):3653. doi: 10.3390/ijms22073653

Figure 1.

Figure 1

miR-483-5p predicted binding to mRNAs from ERK1 (MAPK3) and ERK2 (MAPK1). (A) Top 8 out of 1818 predicted targets of miR-483-5p from TargetScan 7.2 (based on context++ score) and the overlap with four experimentally-validated targets of miR-483-5p in miRTarBase 7.0. (B) Common targets predicted from TargetScan 7.2 for miR-483-5p and the neuroprotective miR-132-3p. (C) Table of predicted miRNA affinities for TAU (MAPT), ERK1 (MAPK3) and ERK2 (MAPK1) mRNAs in AD literature. LA = Luciferase assay, RT-qPCR = Reverse transcriptase quantitative PCR, IMB = Immunoblotting, N/A = Not available. The superscripted numbers indicate references where these interactions were verified.