5-CK	5-O-methylcneorumchromone K
GABA	Gamma aminobutyric acid
NSAID	non-steroidal anti-inflammatory drugs
ANOVA	analysis of variance
ip.	intraperitoneal
CTRL	control group
SEM	standard error of the mean
PDB	Protein Data Bank
PLIP	Protein-Ligand Interaction Profiler
RSMD	root-mean-square deviation
K+ATP	ATP-sensitive potassium channel
4-PIOL	(3-hydroxy-5-(4-piperidyl) isoxazole)
THIP	4,5,6,7-tetrahydroisoxazolo[5,4-c] pyridin-3-ol
FIOCRUZ	Oswaldo Cruz Foundation
Cryo-EM	Cryogenic electron microscopy