Figure 1.

Salubrinal alleviated the clinical symptoms of collagen-induced arthritis (CIA) mice. CIA was induced in DBA/1J mice by subcutaneous injection with CII on day 0 and day 21. Mice were injected intraperitoneally with vehicle or Salubrinal daily beginning on day 21 and were sacrificed on day 37. (A) Clinical score for arthritis and body weight (n = 6/group). (B) Representative H&E staining of ankle joint sections. (C) Representative three-dimensional renditions of the ankle joints and paws using micro-CT. (D) Tartrate-resistant acid phosphatase (TRAP) staining on the knee joints. Arrows indicate wine red areas. Data are shown as means ± SEM. * p < 0.05.