Figure 1.

Dextran sulfate sodium (DSS) colitis – induced body weight changes in mice consuming diets of differing dietary iron levels. (a) Percentage weight loss observed in mice with chronic colitis induced by three cycles of 1.25% w/v DSS during the 63-day period was not influenced by consumption of an iron-deficient diet (100 ppm iron [blue]), standard chow diet (200 ppm iron [red]) nor an iron supplemented diet (400 ppm iron [green]); Data presented as mean ± standard error of the mean (SEM). No statistical differences were seen between groups (n = 8 mice per group). (b) Percentage body weight loss in mice resulting from DSS-induced acute colitis on 63 days on deficient and supplemented iron diets compared with standard chow (n = 4 female mice per group). Statistical differences * p < 0.05, ** p < 0.01, *** p < 0.001; Kruskal–Wallis test followed by multiple comparison tests.