Table 1.
Correlation between TGFβR3 and clinicopathologic parameters.
| TGFβR3 Expression in Tumor with Respect to Adjacent Non-Tumor Tissue (n = 100) | |||
|---|---|---|---|
| Clinical Parameter | Fold Change ≤ 2 | Fold Change > 2 | p Value |
| Gender (n) | 0.794 | ||
| Male | 50 | 29 | |
| Female | 14 | 7 | |
| Age (years) # | 0.1 | ||
| ≤60 | 35 | 16 | |
| >60 | 25 | 24 | |
| Hepatitis B carrier | 1.0 | ||
| Positive | 43 | 25 | |
| Negative | 20 | 12 | |
| AFP(ng/mL) | 0.014 *^ | ||
| Abnormal (>20) | 45 | 17 | |
| Normal (<20) | 17 | 21 | |
| Aspartate transaminase (U/L) | 0.33 | ||
| Abnormal (>40) | 41 | 21 | |
| Normal (≤40) | 21 | 17 | |
| Venous infiltration | 0.086 | ||
| Present | 40 | 16 | |
| Absent | 24 | 20 | |
| Size of tumor (cm) | 0.239 | ||
| Large (>5) | 38 | 18 | |
| Small (≤5) | 24 | 20 | |
| No. of nodules (n) | 0.806 | ||
| Multiple (>1) | 22 | 15 | |
| Single (1) | 40 | 23 | |
| UICC grade | 0.010 **^ | ||
| Early stage (1,2) | 19 | 16 | |
| Late stage (3,4) | 19 | 46 | |
| Edmonson grade (differentiated) | 0.003 **^ | ||
| Well | 9 | 6 | |
| Moderately | 32 | 25 | |
| Poorly | 23 | 5 | |
| AJCC grade (stage) | 0.048 *^ | ||
| I | 15 | 19 | |
| II | 23 | 12 | |
| IIIA | 20 | 11 | |
| Ex- and intra hepatic recurrence | 0.48 | ||
| Present | 37 | 19 | |
| Absent | 25 | 19 | |
Analyzed by Fisher’s exact test. * p < 0.05, ** p < 0.01. ^ Negative correlation, i.e., Pearson’s R value < 0. # Median age of TGFβR3 expression was 57.5 for fold change ≤2 group and 56 for fold change >2.