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. 2021 Mar 24;22(7):3335. doi: 10.3390/ijms22073335

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Concentration-dependent vasopressin V_1AR antagonist effect of (A) reference antagonist (d(CH₂)5¹,Tyr(Me)₂]-vasopressin (AVP)) and (B) active compounds from Cassia seeds (aurantio-obtusin and 2-hydroxyemodin 1-methylether). Reference drugs and test samples were tested at the indicated concentration for antagonist effect by determining the percentage inhibition of control response to 10 nM AVP. (B) Represents a comparative inhibition pattern of aurantio-obtusin with its substructure, 2-hydroxyemodin 1-methylether. Values are expressed as mean ± SD of triplicate experiment.