. 2021 Mar 31;22(7):3640. doi: 10.3390/ijms22073640

Table 2.

OncomiRs and TS miRNAs dysregulated in EC, their putative targets and the biological materials evaluated in the studies.

miRNA	Role in EC	Putative Target(s)	Evaluated Material(s)
miR-675-3p	OncomiR	E-cadherin, MMP2, MMP9	PS
miR-21	OncomiR	PTEN, PDCD4, KRAS	PS
miR-92a	OncomiR	PTEN, Bax/Bcl-2/caspase-3 axis;	CL (normal and cancerous)
miR-92a	OncomiR	E-cadherin	PS
miR-155	OncomiR	TP53INP1	PS, CL
miR-155	OncomiR	MAP3K10	CL (cancerous)
miR-543	OncomiR	cPLA2	PS, CL
miR-27a	OncomiR	FBXW7	PS
miR-200a	OncomiR	RKIP, PTEN, APC, E-cadherin	CL (cancerous)
miR-20b	OncomiR	PTEN	PS, CL
miR-371-373 cluster	OncomiR	p53, LATS2	PS
miR-9	OncomiR	E-cadherin	PS, CL
miR-183	OncomiR	PDCD4	PS, CL
		FOXO1	PS, CL
		ABI3BP	CL (normal and cancerous)
miR-223	OncomiR	FBXW7/hCdc4 axis	PS
miR-200b	TS miRNA	CDK2/PAF axis	CL (cancerous)
miR-200b	TS miRNA	Kindlin-2	PS
miR-124	TS miRNA	NRP1, PDCD6, STAT3	PS, CL
miR-126	TS miRNA	VEGF-A	CL, XE
miR-126	TS miRNA	PIK3R2, ADAM9	PS, CL
miR-148a	TS miRNA	ACVR1, MAP3K	PS, CL
miR-26a	TS miRNA	COX-2	PS, CL, XE
miR-26a	TS miRNA	MYCBP	PS, CL
miR-199 family	TS miRNA	AK4, MAP3K11	CL
miR-199 family	TS miRNA	PAK4	PS, CL
miR-195	TS miRNA	Cdc42, HMGA2	PS, CL
miR-195	TS miRNA	YAP1	CL (normal and cancerous)
miR-27a	TS miRNA	KRAS	CL (normal and cancerous), XE
miR-375	TS miRNA	MTDH, SP1, MMP13	TS, CL
miR-133b	TS miRNA	FSCN, Snail1	PS, CL, XE
miR-133b	TS miRNA	EGFR	PS, CL
miR-143	TS miRNA	LASP1, QKI-5	PS, CL
miR-143	TS miRNA	HK2	PS, CL, XE
miR-125b	TS miRNA	HMGA2	CL (cancerous)
miR-125b	TS miRNA	HAX-1	PS, CL

Abbreviations: TS = tumor suppressive; EC = esophageal cancer; Patient Samples (cancer and paired normal esophageal tissue) = PS; Cell Lines = CL; Xenograft = XE.