Table 2.

Summary of the functions of DUB enzymes described in this review.

Name	Role	Cancer Type	Function	Test Model	Reference
BAP1	Tumor suppressor	Lung, Osteosarcoma, Colon	DNA double-strand repair	In vitro	[80,81,82]
	Tumor suppressor	Renal	Ferroptosis signaling	In vitro	[83]
USP7	Oncogene	Cervical	Self-renewal; Foxp3 signaling	In vitro	[84]
	Oncogene	Non-small cell lung	Immune Response; Foxp3 signaling	In vitro	[85]
	Oncogene	Lung	p53 signaling	In vitro, in vivo	[86]
USP22	Oncogene	Lung	Cell Cycle	In vitro	[87]
	Oncogene	Lung adenocarcinoma	EGFR-TKI resistance	In vitro, in vivo	[88]
	Oncogene	Colon	CCNB1 signaling	In vitro, in vivo	[89]
	Oncogene	Glioblastoma	KDM1A signaling	In vitro, in vivo	[90]
UCHL1	Oncogene	Breast	Drug resistance; Invasion/migration	In vitro	[91]
Ataxin 3	Oncogene	Breast, Osteosarcoma, Cervical, Colorectal	DNA	In vitro	[92]
	Oncogene	Testicular	mTOR/Akt signaling	In vitro	[93]
PSMD11	Oncogene	Cervical. Osteosarcoma	DNA damage response	In vitro	[94]
	Oncogene	Lung, Prostate, Colorectal, Breast, Cervix	Cell cycle	In vitro	[95]
	Oncogene	Liver	E2F1 signaling	In vitro, in vivo	[96]
A20	Tumor suppressor	Colorectal	Apoptosis signaling	In vitro	[97]
	Tumor suppressor	Diffuse large B-cell lymphoma	NF-κβ signaling	In vitro	[98]
	Tumor suppressor	Sarcoma	NF-κβ signaling	In vitro	[99]