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. 2021 Mar 26;22(7):3449. doi: 10.3390/ijms22073449

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© 2021 by the author.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Age-related decrease in the number and density of proliferating cells in the CMS, RMS, midlayer, and SGZ. (A) The number of detected proliferating cells in the CMS, RMS, midlayer, and SGZ decreases with mouse age. The means of the number of proliferating cells in the CMS are significantly heterogeneous (one-way ANOVA, F4, 5 = 950, p = 2.2 × 10⁻⁷). The means of the number of proliferating cells in the RMS are significantly heterogeneous (one-way ANOVA, F4, 5 = 19, p = 3.1 × 10⁻³). The means of the number of proliferating cells in the midlayer are significantly heterogeneous (one-way ANOVA, F4, 5 = 1783, p = 4.5 × 10⁻⁸). The means of the number of proliferating cells in the SGZ are significantly heterogeneous (one-way ANOVA, F4, 5 = 828, p = 3.1 × 10⁻⁷); (B) the average volume number density of detected proliferating cells in the CMS, RMS, midlayer, and SGZ decreases with mouse age; (C) The number of detected proliferating cells in the subependymal zone (SEZ) and other parts of the CMS decreases with mouse age; (D) the average volume number density of detected proliferating cells in the SEZ and other parts of the CMS decreases with mouse age.