Table 1.

Experimental populations where TLR activation has been documented and the relevant subtypes of TLRs involved in the pathogenesis of hypertension according to organ system.

Organ System	TLR Subtype	Experimental Populations
Central Nervous System	TLR4 TLR7 TLR8 TLR9	Normotension [23] Pre-hypertensive SHRs [24] SHRs [25,26] AngII-induced hypertension [27,28]
Vascular System	TLR2 TLR4 TLR9	Normotension [29] SHRs [29,30,31,32] AngII-induced hypertension [33] L-NAME induced hypertension [34]
Renal System	TLR4	AngII-induced hypertension [35] Aldosterone-induced hypertension [36]

AngII: angiotensin II; L-NAME: NG-nitro-L-arginine methyl ester; SHRs: spontaneously hypertensive rats; TLR: toll-like receptor.