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. 2021 Mar 30;22(7):3569. doi: 10.3390/ijms22073569

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(A) Left ventricular mass (LVM) indexed for body surface area (BSA) and myocardial external efficiency (MEE) indexed for BSA. Data shown as mean + standard deviation. * p < 0.05 vs. Controls ^# p < 0.05 vs. AS before AVR. (B) Scatterplots of correlations between LVMi and MEEi and 4 metabolites of the top 30 metabolic profile that correlate strongly of which 3 show a pattern of normalization towards control after AVR: 9′-carboxy-gamma-tocotrienol (left), 3-polyprenyl-4,5-dihydroxybenzoate (middle) and phenylalanyl-asparagine/asparaginyl-phenylalanine (right).