Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Mar 25;13(7):1509. doi: 10.3390/cancers13071509

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Densely connected protein networks based on proteins which were two-fold increased or four-fold decreased in the MSC/AML-CM culture supernatants compared to AML-CM (i.e., corresponding AML cells cultured alone). Proteins with significantly altered protein abundance were imported to String for protein interaction network analysis. The protein networks were further imported to Cytoscape where the MCODE application was used to find closely connected protein networks containing at least five proteins. The GO annotations were identified by the String database. Red color indicates increased abundance in MSC/AML-CM and blue color indicates decreased abundance in MSC/AML-CM relative to AML-CM. BP, biological processes; CC, cellular compartment; Uniprot KW, Uniprot Keywords; ECM, extracellular matrix; ER, endoplasmic reticulum.