Table 2.
GO analysis of all gene/protein names identified in this study, i.e., all proteins identified for the MSCs cultured alone, 40 primary AML cells cultured alone (AML-CM) and/or MSCs cultured in the presence of AML-conditioned medium (MSC/AML-CM). The presentation is based on a bioinformatical analysis of GO terms/cellular compartment, and the list presents all terms that included at least 100 of the identified proteins (hypergeometric test, Bonferroni correction). The data are presented as the number of proteins associated to a given term, number of proteins in the background dataset, percent of proteins in the dataset annotated to a given GO term, the fold enrichment and the p-values.
| Cellular Compartment | Number of Proteins | Proteins in the Background Dataset |
Percent of Proteins | Fold Enrichment |
p-Value (Hypergeometric Test) |
Bonferroni Corrected |
|---|---|---|---|---|---|---|
| Cytoplasm | 1171 | 5684 | 68.4 | 1.8 | 2.2 × 10−151 | 1.7 × 10−148 |
| Nucleus | 946 | 5847 | 55.3 | 1.4 | 2.83 × 10−41 | 2.22 × 10−38 |
| Exosomes | 746 | 2043 | 43.6 | 3.1 | 5.8 × 10−232 | 4.5 × 10−229 |
| Lysosome | 561 | 1620 | 32.8 | 2.9 | 1.8 × 10−151 | 1.4 × 10−148 |
| Nucleolus | 443 | 1257 | 25.9 | 3.0 | 1.4 × 10−118 | 1.1 × 10−115 |
| Cytosol | 407 | 1178 | 23.8 | 2.9 | 1.5 × 10−104 | 1.1 × 10−101 |
| Mitochondrion | 348 | 1259 | 20.3 | 2.4 | 2.36 × 10−59 | 1.85 × 10−56 |
| Centrosome | 343 | 656 | 20.0 | 4.4 | 4.8 × 10−152 | 3.7 × 10−149 |
| Plasma membrane | 316 | 3479 | 18.5 | 0.8 | 1 | 1 |
| Extracellular | 262 | 1825 | 15.3 | 1.2 | 0.000182 | 0.14294 |
| Endoplasmic reticulum | 148 | 1104 | 8.6 | 1.1 | 0.044427 | 1 |
| Cytoskeleton | 137 | 427 | 8.0 | 2.7 | 7.52 × 10−30 | 5.89 × 10−27 |
| Golgi apparatus | 127 | 897 | 7.4 | 1.2 | 0.013653 | 1 |
| Nucleoplasm | 106 | 449 | 6.2 | 2.0 | 7.13 × 10−13 | 5.59 × 10−10 |