Table 3.
Hierarchical clustering of AML patients based on the constitutive protein release profiles of their leukemic cells during in vitro culture. The table gives an overview of the most significant GO terms for each of the five identified protein clusters (see Figure 4, upper part indicating the protein clustering). For each of the five protein clusters, we present the five most significant GO terms (Cellular compartment).
| Cluster and Corresponding Go Terms | p-Value (Uncorrected) | FDR |
|---|---|---|
| Left purple protein cluster | ||
| Mitochondrial part | 7.77 × 10−8 | 4.68 × 10−5 |
| Ribosomal subunit | 1.72 × 10−6 | 0.000345 |
| Organelle inner membrane | 1.41 × 10−5 | 0.00212 |
| Cytosolic part | 1.48 × 10−5 | 0.00212 |
| Mitochondrion | 1.86 × 10−5 | 0.00212 |
| Middle left green protein cluster | ||
| Nucleoplasm part | 7.69 × 10−7 | 0.000557 |
| Nucleoplasm | 0.000116 | 0.0168 |
| Spliceosomal complex | 0.000621 | 0.0749 |
| Nuclear chromosome part | 0.00125 | 0.113 |
| Nucleoplasm part | 7.69 × 10−7 | 0.000557 |
| Middle yellow protein cluster | ||
| Extracellular exosome | 4.72 × 10−17 | 2.97 × 10−14 |
| Cytoplasmic vesicle part | 1.68 × 10−9 | 1.76 × 10−7 |
| Cytosol | 1.80 × 10−9 | 1.76 × 10−7 |
| Extracellular region | 1.42 × 10−8 | 1.11 × 10−6 |
| Vesicle lumen | 1.42 × 10−7 | 7.43 × 10−6 |
| Middle right orange protein cluster | ||
| Extracellular matrix organization | 2.67 × 10−10 | 1.33 × 10−6 |
| Anatomical structure morphogenesis | 1.96 × 10−5 | 0.0325 |
| Positive regulation of developmental process | 0.000231 | 0.231 |
| Vesicle-mediated transport | 0.000237 | 0.231 |
| Multicellular organismal process | 0.000243 | 0.231 |
| Right blue protein cluster | ||
| No significant GO terms |