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. 2021 Mar 30;10(7):1384. doi: 10.3390/jcm10071384

Table 2.

Common SNPs and ILDs.

Gene SNP Disease OR (95% CI) and p-Value Population Cohort Size (Patients/Controls) Reference
TERT rs2736100 IPF OR = 2.11 (1.61–2.78)
p = 2.9 × 10−8
Japanese 242 /1469 Mushiroda et al. [65]
Non-IPF ILD OR = 1.43 (1.11–1.85)
p = 6.2 × 10−3
European 143/689 Wei et al. [66]
IPF OR = 1.08 (0.78–1.49)
p > 0.05
European 84/689 Wei et al. [66]
IIP OR not given
p = 1.7 × 10−19
European 2492 /6573 Fingerlin et al. [67]
IPF OR = 0.5
p = 0.05
Mexican 83/111 Peljto et al. [68]
IPF OR = 0.57
p = 0.17
Korean 239/87 Peljto et al. [68]
rs2853676 IIP OR not given
p = 3.3 × 10−8
European 2492 /6573 Fingerlin et al. [67]
TERC rs1881984 IIP OR not given
p = 4.5 × 10−8
European 2492 /6573 Fingerlin et al. [67]

Meta-analysis of a discovery and replication cohort. IPF: Idiopathic Pulmonary Fibrosis, ILD: Interstitial Lung Disease, IIP: Idiopathic Interstitial Fibrosis.