Table 2.
Gene | SNP | Disease | OR (95% CI) and p-Value | Population | Cohort Size (Patients/Controls) | Reference |
---|---|---|---|---|---|---|
TERT | rs2736100 | IPF | OR = 2.11 (1.61–2.78) p = 2.9 × 10−8 |
Japanese | 242 ‡/1469 | Mushiroda et al. [65] |
Non-IPF ILD | OR = 1.43 (1.11–1.85) p = 6.2 × 10−3 |
European | 143/689 | Wei et al. [66] | ||
IPF | OR = 1.08 (0.78–1.49) p > 0.05 |
European | 84/689 | Wei et al. [66] | ||
IIP | OR not given p = 1.7 × 10−19 |
European | 2492 ‡/6573 | Fingerlin et al. [67] | ||
IPF | OR = 0.5 p = 0.05 |
Mexican | 83/111 | Peljto et al. [68] | ||
IPF | OR = 0.57 p = 0.17 |
Korean | 239/87 | Peljto et al. [68] | ||
rs2853676 | IIP | OR not given p = 3.3 × 10−8 |
European | 2492 ‡/6573 | Fingerlin et al. [67] | |
TERC | rs1881984 | IIP | OR not given p = 4.5 × 10−8 |
European | 2492 ‡/6573 | Fingerlin et al. [67] |
‡ Meta-analysis of a discovery and replication cohort. IPF: Idiopathic Pulmonary Fibrosis, ILD: Interstitial Lung Disease, IIP: Idiopathic Interstitial Fibrosis.