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. Author manuscript; available in PMC: 2022 Apr 1.
Published in final edited form as: FASEB J. 2021 Apr;35(4):e21448. doi: 10.1096/fj.202002471R

Figure 1. Pro-resolving lipid mediator measurement and correlation with EPA, DHA and omega-3 fatty acid index.

Figure 1

(A) Representative Multiple Reaction Monitoring Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS) Chromatograms of Selected Ion Pairs for Lipid Mediators. 18-HEPE, resolvin E1, maresin 1 and 17-HDHA are reported along with representative MS/MS spectra and diagnostic ions employed for their identification; representative of n = 31. M/Z represents molecular mass divided by charge state.

(B) Heat map representing the Pearson correlation coefficients between the precursors, eicosapentaenoic acid, docosahexaenoic acid and omega-3 fatty acid index, and their downstream lipid mediator products at 30-month follow-up. Numerical data are in Supplemental Table 1.

17-HDHA, 17-hydroxy-docosahexaenoic acid; 18-HEPE, 18-hydroxy-eicosapentaenoic acid; DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid; MaR1, maresin 1; PGD2, prostaglandin D2; RvE1, resolvin E1.

* P<0.05, **P<0.01, ***P<0.001, Pearson correlation.