Table 3.

Review of the literature on radiotherapy outcomes of pulmonary ACC

Authors	No. of patients	Radiotherapy dose, BED2Gy	Follow-up (months)	Combination therapy	Treatment outcome	Adverse events
Bhandari V [11]	1	54 Gy/30fr., 102.6 Gy	8	–	No evidence of recurrence	Bronchial stricture grade 1
Das S [13]	1	66 Gy/33 fr., 132 Gy	38	–	Local recurrence	NR
Haresh KP [14]	1	60 Gy/30 fr., 120 Gy	19	–	No evidence of recurrence	NR
Kanematsu T [15]	5	50–70 Gy (median 60 Gy), 100–140 Gy (median 120 Gy)	NR	–	Local recurrence in all five cases (5-year OS, 40%; 10-year OS, 0%)	NR
Kim B [16]	1	66 Gy/33 fr., 132 Gy	20	Paclitaxel, cisplatin, docetaxel, gefitinib	Dead without local recurrence	Radiation pneumonitis grade 1
Lee JH [17]	12	60 Gy/30 fr., 120 Gy	8–167 (median 59)	–	5 year OS, 54%; 10-year OS, 27%	NR
Liu J [18]	1	65 Gy/35 fr. + endobronchial boost 10 Gy/1 fr., 125.4 Gy + 60 Gy	90	Cisplatin	Local recurrence	Esophagitis grade 3, skin reaction grade 1, and bronchial stricture grade 1

fr. fractions, BED biologically equivalent dose, OS overall survival, LC local control, NR not reported