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. 2021 Mar 31;22(7):3641. doi: 10.3390/ijms22073641

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Regulation of saliva-induced interleukin-8 (IL-8) expression in THP-1 cells via the IKK2/IκBα/NF-κB pathway. (A) mRNA expression levels of IL-8 in cells exposed to saliva (5%) and control cells. Effects of IKK2 and NF-κB inhibitors (BMS-345541 and BAY 11-7082, respectively) on saliva-induced mRNA expression of IL-8 in THP-1 cells. Data represent the mean ± standard error of the mean (n = 3). *** p < 0.001 compared to control group; ^## p < 0.01 compared to saliva-treated group (Student’s t-test). (B) Working scheme for the regulation of saliva-induced IL-8 expression via the IKK2/IκBα/NF-κB pathway. Blue arrow = stimulation; red line with an end bar = inhibition; black arrow = direction or flow.